An integrin's gut instincts
نویسندگان
چکیده
منابع مشابه
Gut instincts: CYP3A4 and intestinal drug metabolism.
First-pass metabolism is a common cause of incomplete and variable absolute bioavailability for an orally dosed drug. The drug-metabolizing enzyme CYP3A4 is often implicated in this process, resulting, in some cases, in systemic exposures of less than 15% of the administered dose. By creating an elegant CYP3A4-transgenic mouse model, van Herwaarden et al. show in this issue of the JCI that firs...
متن کاملGut instincts: thoughts on intestinal epithelial stem cells.
surface of the gastrointestinal tract is lined by a simple columnar epithelium that is folded to form a number of invaginations, or crypts, that are embedded in the connective tissue. Each crypt contains approximately 250 cells, depending on its species and anatomical location. Crypt size and organization are generally uniform within a given region of the gastrointestinal tract (1). Of the majo...
متن کاملGut instincts: explorations in intestinal physiology and drug delivery.
We need to look beyond our gut instincts to use information on "simple" intestinal physiological parameters as they have been presented to us in the past. Here we present a discussion on such parameters, old and new, and ask how much we really understand them. Behaviour of drugs and delivery systems in the intestine depends on many physiological factors including fluid volume, fluid composition...
متن کاملCorrection: Gut Instincts: Knowledge, Attitudes, and Practices regarding Soil-Transmitted Helminths in Rural China
[This corrects the article DOI: 10.1371/journal.pntd.0003643.].
متن کاملGut Instincts: Knowledge, Attitudes, and Practices regarding Soil-Transmitted Helminths in Rural China
BACKGROUND Soil-transmitted helminth (STH) infections affect more than two out of every five schoolchildren in the poorest regions of rural China, an alarmingly high prevalence rate given the low cost and wide availability of safe and effective deworming treatment. Understanding of local knowledge, attitudes, and practices regarding STH infection in rural China has until now, been sparse, altho...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1753iti1